Article
Ubiquitination regulates the neuroprotective function of the deubiquitinase ataxin-3 in vivo.
The Journal of biological chemistry - 29 Nov 2013
Tsou Wei-Ling, Burr Aaron A, Ouyang Michelle, Blount Jessica R, Scaglione K Matthew, Todi Sokol V
Abstract excerpt
Deubiquitinases (DUBs) are proteases that regulate various cellular processes by controlling protein ubiquitination. Cell-based studies indicate that the regulation of the activity of DUBs is important for homeostasis and is achieved by multiple mechanisms, including through their own ubiquitination. However, the physiological significance of the ubiquitination of DUBs to their functions in vivo is unclear. Here,...
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