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Article

Drosophila stem cells share a common requirement for the histone H2B ubiquitin protease scrawny.

Science (New York, N.Y.) - 9 Jan 2009

Buszczak Michael, Paterno Shelley, Spradling Allan C

Abstract excerpt

Stem cells within diverse tissues share the need for a chromatin configuration that promotes self-renewal, yet few chromatin proteins are known to regulate multiple types of stem cells. We describe a Drosophila gene, scrawny (scny), encoding a ubiquitin-specific protease, which is required in germline, epithelial, and intestinal stem cells. Like its yeast relative UBP10, Scrawny deubiquitylates histone H2B and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19039105
DOI: 10.1126/science.1165678
PMCID: PMC2759887

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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