Article

Impact of Propionic Acidemia on Brain Astrocytes

2021-02-08

Abstract excerpt

<h4>ABSTRACT</h4> Propionic acidemia (PA) is an inborn error of metabolism (IEM) caused by mutations in the enzyme propionyl CoA carboxylase (PCC). It is characterized by the inability to break down branched chain amino acids and odd chain fatty acids, causing a buildup of toxic organic acids in blood. PA affects every organ in the body with particularly severe manifestations in the brain, like hyperammonemia, hy...

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Literature Corpus work: 4e03fed6-f1d5-571a-b5f1-7671753101bc
DOI: 10.1101/2021.02.07.428966

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