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Article

Phenotypic conversions of "protoplasmic" to "reactive" astrocytes in Alexander disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 24 Apr 2013

Sosunov Alexander A, Guilfoyle Eileen, Wu Xiaoping, McKhann Guy M, Goldman James E

Abstract excerpt

Alexander Disease (AxD) is a primary disorder of astrocytes, caused by heterozygous mutations in GFAP, which encodes the major astrocyte intermediate filament protein, glial fibrillary acidic protein (GFAP). Astrocytes in AxD display hypertrophy, massive increases in GFAP, and the accumulation of Rosenthal fibers, cytoplasmic protein inclusions containing GFAP, and small heat shock proteins. To study the effects...

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Source

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Identifiers

PMID: 23616550
DOI: 10.1523/JNEUROSCI.4506-12.2013
PMCID: PMC3694721

Genes

GFAP
CD44

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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