Article

Metabolic, epigenetic and transcriptomic alterations in postnatal 16p11.2-deficient murine astrocytes

2025-12-17

Abstract excerpt

<h4>SUMMARY</h4> Autism Spectrum Disorders (ASD) are associated with metabolic dysregulation. While astrocytes are integral to cerebral metabolism, their molecular and functional changes in ASD are poorly known. Using early postnatal primary cortical astrocytes from a mouse model of 16p11.2 deletion ASD syndrome ( 16p11.2 df/+ mice), we observed core molecular alterations with sex-specific profiles, suggesting...

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Literature Corpus work: 700cb2eb-498c-57d3-9a32-b59beecc2dd0
DOI: 10.64898/2025.12.16.694710

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