Article
Selectin haplotypes and the risk of venous thrombosis: influence of linkage disequilibrium with the factor V Leiden mutation.
Journal of thrombosis and haemostasis : JTH - 1 Mar 2008
Uitte de Willige S, De Visser M C H, Vos H L, Houwing-Duistermaat J J, Rosendaal F R, Bertina R M
Abstract excerpt
BACKGROUND: Selectins (E-, L- and P-selectin) and their most important counter-receptor P-selectin glycoprotein ligand (SELPLG) facilitate the interaction of platelets, leukocytes and endothelial cells at inflammatory sites. Selectin polymorphisms/haplotypes have been associated with cardiovascular disease. OBJECTIVES: We investigated the association between haplotypes (H) of these four genes and deep venous...
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