Article
The risk for thromboembolic disease in lupus anticoagulant patients due to pathways involving P-selectin and CD154.
Thrombosis and haemostasis - 1 Apr 2007
Bugert Peter, Pabinger Ingrid, Stamer Kathrin, Vormittag Rainer, Skeate Robert C, Wahi Monika M, Panzer Simon
Abstract excerpt
Individuals with lupus anticoagulants (LA) are at risk for thromboembolism (TE). Chronic inflammation is an important characteristic in LA patients which may dispose for TE. Platelets play a key role in inflammation and TE. We therefore investigated gene polymorphisms as well as plasma levels of platelet receptors as predictors of TE in 107 LA patients. We compared 74 patients with a history of thromboembolic...
Topics
- Adult
- CD40 Ligand
- Cohort Studies
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Logistic Models
- Lupus Coagulation Inhibitor
- Male