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Article

Elevated brain serotonin turnover in patients with depression: effect of genotype and therapy.

Archives of general psychiatry - 1 Jan 2008

Barton David A, Esler Murray D, Dawood Tye, Lambert Elisabeth A, Haikerwal Deepak, Brenchley Celia, Socratous Florentia, Hastings Jacqueline, Guo Ling, Wiesner Glen, Kaye David M, Bayles Richard, Schlaich Markus P, Lambert Gavin W

Abstract excerpt

CONTEXT: The biological basis for the development of major depressive disorder (MDD) remains incompletely understood. OBJECTIVE: To quantify brain serotonin (5-hydroxytryptamine [5-HT]) turnover in patients with MDD. DESIGN: Patients with depression were studied both untreated and during administration of a selective serotonin reuptake inhibitor (SSRI) in an unblinded study of sequential design. Healthy...

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Identifiers

PMID: 18180427
DOI: 10.1001/archgenpsychiatry.2007.11

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HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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