Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls.

doi:10.1001/archpsyc.63.9.978

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Article

Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls.

Archives of general psychiatry - 1 Sept 2006

Neumeister Alexander, Hu Xian-Zhang, Luckenbaugh David A, Schwarz Markus, Nugent Allison C, Bonne Omer, Herscovitch Peter, Goldman David, Drevets Wayne C, Charney Dennis S

Abstract excerpt

CONTEXT: Tryptophan depletion (TD) is a model used to study the contribution of reduced serotonin transmission to the pathogenesis of major depressive disorder (MDD). Recent studies have not sufficiently addressed the relative contribution of a functional-length triallelic polymorphism in the promoter of the serotonin transporter, 5-HTTLPR, to the behavioral and neural responses to TD in individuals with remitted...

Topics

Adult
Ambulatory Care
Amino Acids
Brain
Depressive Disorder, Major
Double-Blind Method
Female
Fluorodeoxyglucose F18
Genotype
Glucose

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Neural Pathways

Placebos

Polymorphism, Single Nucleotide

Positron-Emission Tomography

Prospective Studies

Psychiatric Status Rating Scales

Source

Open in PubMed

Identifiers

PMID: 16953000
DOI: 10.1001/archpsyc.63.9.978

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