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Article

Serotonin transporter genotype and depressive phenotype determination by discriminant analysis of glucose metabolism under acute tryptophan depletion.

NeuroImage - 1 Dec 2008

Nugent Allison C, Neumeister Alexander, Goldman David, Herscovitch Peter, Charney Dennis S, Drevets Wayne C

Abstract excerpt

Acute tryptophan depletion (ATD) putatively results in a transient reduction in central serotonin transmission, and induces depressed mood in some un-medicated subjects with remitted major depressive disorder (MDD). The 5-HT transporter promoter region length polymorphism (5-HTTLPR) has been shown to influence behavioral and metabolic responses to ATD, as well as the risk for developing MDD within the context of...

Topics

Adult
Brain
Depression
Discriminant Analysis
Female
Fluorodeoxyglucose F18
Genetic Predisposition to Disease
Glucose
Humans
Male
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Placebo Effect

Positron-Emission Tomography

Radiopharmaceuticals

Serotonin Plasma Membrane Transport Proteins

Tryptophan

Source

Open in PubMed Open full text

Identifiers

PMID: 18718871
DOI: 10.1016/j.neuroimage.2008.07.040
PMCID: PMC2650221

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