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Article

Serotonin transporter genotype and depressive phenotype determination by discriminant analysis of glucose metabolism under acute tryptophan depletion.

NeuroImage - 1 Dec 2008

Nugent Allison C, Neumeister Alexander, Goldman David, Herscovitch Peter, Charney Dennis S, Drevets Wayne C

Abstract excerpt

Acute tryptophan depletion (ATD) putatively results in a transient reduction in central serotonin transmission, and induces depressed mood in some un-medicated subjects with remitted major depressive disorder (MDD). The 5-HT transporter promoter region length polymorphism (5-HTTLPR) has been shown to influence behavioral and metabolic responses to ATD, as well as the risk for developing MDD within the context of...

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Identifiers

PMID: 18718871
DOI: 10.1016/j.neuroimage.2008.07.040
PMCID: PMC2650221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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