Article
The power of sample size and homogenous sampling: association between the 5-HTTLPR serotonin transporter polymorphism and major depressive disorder.
Biological psychiatry - 1 Feb 2005
Hoefgen Barbara, Schulze Thomas G, Ohlraun Stephanie, von Widdern Olrik, Höfels Susanne, Gross Magdalena, Heidmann Vivien, Kovalenko Svetlana, Eckermann Anita, Kölsch Heike, Metten Martin, Zobel Astrid, Becker Tim, Nöthen Markus M, Propping Peter, Heun Reinhard, Maier Wolfgang, Rietschel Marcella
Abstract excerpt
BACKGROUND: Several lines of evidence indicate that abnormalities in the functioning of the central serotonergic system are involved in the pathogenesis of affective illness. A 44-base-pair insertion/deletion polymorphism in the 5' regulatory region of the serotonin transporter gene (5-HTTLPR), which influences expression of the serotonin transporter, has been the focus of intensive research since an initial...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.