Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hepatocyte–Stellate Cell Cross-Talk in the Liver Engenders a Permissive Inflammatory Microenvironment That Drives Progression in Hepatocellular Carcinoma

14 Mar 2012

Abstract excerpt

Many solid malignant tumors arise on a background of inflamed and/or fibrotic tissues, features that are found in more than 80% hepatocellular carcinomas (HCC). Activated hepatic stellate cells (HSC) play a critical role in fibrogenesis associated with HCC onset and progression, yet their functional impact on hepatocyte fate remains largely unexplored. Here, we used a coculture model to investigate the cross-talk...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Ferroptosis and cancer prognosis
Share to Liver physiology and pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22419664
DOI: 10.1158/0008-5472.can-11-3317

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hepatocyte–Stellate Cell Cross-Talk in the Liver Engenders a Permissive Inflammatory Microenvironment That Drives Progression in Hepatocellular CarcinomaPMID 22419664Read ↗

Hepatic stellate cells and extracellular matrix in hepatocellular carcinoma: more complicated than everSemantic proximity Read ↗

Unraveling the activation process and core driver genes of HSCs during cirrhosis by single-cell transcriptomeSemantic proximity Read ↗

Hepatic stellate cell heterogeneity: Functional aspects and therapeutic implicationsSemantic proximity Read ↗

Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cellsSemantic proximity Read ↗

Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesisSemantic proximity Read ↗

Hepatic fibrogenesis in response to chronic liver injury: novel insights on the role of cell-to-cell interaction and transition.Semantic proximity Read ↗

Hepatic stellate cells limit hepatocellular carcinoma progression through the orphan receptor endosialinSemantic proximity Read ↗

Cellular crosstalk during liver regeneration: unity in diversitySemantic proximity Read ↗

An Integrated Single-Cell Atlas Reveals Hepatic Stellate Cell Heterogeneity and Spatiotemporal Dynamics after Liver InjurySemantic proximity Read ↗

Hierarchical Coculture of Hepatocyte and Hepatic Non-Parenchymal Cells for Liver Fibrosis Studies in vitroSemantic proximity Read ↗

Bile acid-mediated activation of hepatic stellate cells and myeloid cell leukemia- 1 triggers hepatocarcinogenesisSemantic proximity Read ↗

Inflammatory cytokines promote the retrodifferentiation of tumor-derived hepatocyte-like cells to progenitor cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.