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In vitro modeling of liver fibrosis with 3D co‐culture system using a novel human hepatic stellate cell line

14 Jan 2023

Abstract excerpt

Hepatic stellate cells (HSCs) play an important role in liver fibrosis; however, owing to the heterogeneity and limited supply of primary HSCs, the development of in vitro liver fibrosis models has been impeded. In this study, we established and characterized a novel human HSC line (LSC-1), and applied it to various types of three-dimensional (3D) co-culture systems with differentiated HepaRG cells. Furthermore,...

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PMID: 36639871
DOI: 10.1002/bit.28333

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