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Article

An In Vitro Human Liver Model by iPSC-Derived Parenchymal and Non-parenchymal Cells.

Stem cell reports - 8 Aug 2017

Koui Yuta, Kido Taketomo, Ito Toshimasa, Oyama Hiroki, Chen Shin-Wei, Katou Yuki, Shirahige Katsuhiko, Miyajima Atsushi

Abstract excerpt

During liver development, hepatoblasts and liver non-parenchymal cells (NPCs) such as liver sinusoidal endothelial cells (LSECs) and hepatic stellate cells (HSCs) constitute the liver bud where they proliferate and differentiate. Accordingly, we reasoned that liver NPCs would support the maturation of hepatocytes derived from human induced pluripotent stem cells (hiPSCs), which usually exhibit limited functions....

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Identifiers

PMID: 28757162
DOI: 10.1016/j.stemcr.2017.06.010
PMCID: PMC5549957

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