Article
Congenic mapping of a blood pressure QTL region on rat chromosome 10 using the Dahl salt-sensitive rat with introgressed alleles from the Milan normotensive strain.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 2008
Saad Yasser, Toland Edward J, Yerga-Woolwine Shane, Farms Phyllis, Joe Bina
Abstract excerpt
Multiple blood pressure (BP) quantitative trait loci (QTLs) are reported on rat chromosome 10 (RNO10). Of these, QTLs detected by contrasting the genome of the hypertensive Dahl salt-sensitive (S) rat with two different relatively normotensive strains, Lewis (LEW) and the Milan normotensive strain (MNS), are reported. Because the deduced QTL regions of both S vs. LEW and S vs. MNS comparisons are within large...
Topics
- Alleles
- Animals
- Animals, Congenic
- Blood Pressure
- Body Weight
- Chromosome Mapping
- Chromosomes, Mammalian
- Heart
- Inbreeding
- Organ Size
- Quantitative Trait Loci
- Rats
- Rats, Inbred Dahl
- Telemetry