Epistasis, not numbers, regulates functions of clustered Dahl rat quantitative trait loci applicable to human hypertension.

doi:10.1161/01.HYP.0000192024.72367.c3

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Article

Epistasis, not numbers, regulates functions of clustered Dahl rat quantitative trait loci applicable to human hypertension.

Hypertension (Dallas, Tex. : 1979) - 1 Dec 2005

Charron Sophie, Duong Chenda, Ménard Annie, Roy Julie, Eliopoulos Vasiliki, Lambert Raphaëlle, Deng Alan Y

Abstract excerpt

Quantitative trait loci (QTLs) for blood pressure (BP) were found on chromosome 10 of Dahl salt-sensitive rats and are potentially important to human essential hypertension. But their identities and how they influence BP together were not known. Presently, we first fine mapped existing QTLs, C10QTL1, C10QTL2, and C10QTL3, by constructing congenic strains. In the process, a new QTL, C10QTL4, was identified....

Topics

Animals
Animals, Congenic
Blood Pressure
Chromosome Mapping
Epistasis, Genetic
Genetic Predisposition to Disease
Humans
Hypertension
Quantitative Trait Loci
Rats
Rats, Inbred Dahl

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Open in PubMed

Identifiers

PMID: 16286573
DOI: 10.1161/01.HYP.0000192024.72367.c3

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