Article
Construction of a double congenic strain to prove an epistatic interaction on blood pressure between rat chromosomes 2 and 10.
The Journal of clinical investigation - 15 Apr 1998
Rapp J P, Garrett M R, Deng A Y
Abstract excerpt
Previously we presented suggestive evidence from an F2 segregating population for an interaction on blood pressure (BP) between quantitative trait loci (QTL) on rat chromosomes (Chr) 2 and 10. To prove the existence of such an interaction, we developed congenic strains for Chr 2 and 10 by introgr...
Topics
- Alleles
- Animals
- Blood Pressure
- Chromosome Mapping
- Crosses, Genetic
- Epistasis, Genetic
- Female
- Genetic Linkage
- Hypertension
- Male
- Myocardium
- Organ Size
- Quantitative Trait, Heritable
- Rats
- Rats, Inbred Strains
- Rats, Inbred WKY