Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Severe hypertension caused by alleles from normotensive Lewis for a quantitative trait locus on chromosome 2.

Physiological genomics - 16 Jun 2005

Eliopoulos Vasiliki, Dutil Julie, Deng Yishu, Grondin Myrian, Deng Alan Y

Abstract excerpt

Pursuing fully a suggestion from linkage analysis that there might be a quantitative trait locus (QTL) for blood pressure (BP) in a chromosome (Chr) 2 region of the Dahl salt-sensitive rat (DSS), four congenic strains were made by replacing various fragments of DSS Chr 2 with those of Lewis (LEW). Consequently, a BP QTL was localized to a segment of around 3 cM or near 3 Mb on Chr 2 by comparative congenics. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Congenic
Share to Blood Pressure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Mammalian

Share to Hypertension

Share to Quantitative Trait Loci

Share to Rats, Inbred Dahl

Share to Rats, Inbred Lew

Share to Sequence Homology, Nucleic Acid

Source

Identifiers

PMID: 15827238
DOI: 10.1152/physiolgenomics.00019.2005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Severe hypertension caused by alleles from normotensive Lewis for a quantitative trait locus on chromosome 2.PMID 15827238Read ↗

Two closely linked interactive blood pressure QTL on rat chromosome 5 defined using congenic Dahl rats.Semantic proximity Read ↗

Congenic mapping of a blood pressure QTL region on rat chromosome 10 using the Dahl salt-sensitive rat with introgressed alleles from the Milan normotensive strain.Semantic proximity Read ↗

Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats.Semantic proximity Read ↗

Construction of a double congenic strain to prove an epistatic interaction on blood pressure between rat chromosomes 2 and 10.Semantic proximity Read ↗

Congenic strains provide evidence that four mapped loci in chromosomes 2, 4, and 16 influence hypertension in the SHR.Semantic proximity Read ↗

Hypertension Suppression, Not a Cumulative Thrust of Quantitative Trait Loci, Predisposes Blood Pressure Homeostasis to Normotension.Semantic proximity Read ↗

Individual QTLs controlling quantitative variation in blood pressure inherited in a Mendelian mode.Semantic proximity Read ↗

Strategy for uncovering complex determinants of hypertension using animal models.Semantic proximity Read ↗

Cardiac pathways distinguish two epistatic modules enacting BP quantitative trait loci and candidate gene analysis.Semantic proximity Read ↗

Defining a rat blood pressure quantitative trait locus to a <81.8 kb congenic segment: comprehensive sequencing and renal transcriptome analysis.Semantic proximity Read ↗

Fine mapping of epistatic genetic determinants of blood pressure on rat chromosome 5.Semantic proximity Read ↗

Complete and overlapping congenics proving the existence of a quantitative trait locus for blood pressure on Dahl rat chromosome 17.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.