Article
Zasp is required for the assembly of functional integrin adhesion sites.
The Journal of cell biology - 31 Dec 2007
Jani Klodiana, Schöck Frieder
Abstract excerpt
The integrin family of heterodimeric transmembrane receptors mediates cell-matrix adhesion. Integrins often localize in highly organized structures, such as focal adhesions in tissue culture and myotendinous junctions in muscles. Our RNA interference screen for genes that prevent integrin-dependent cell spreading identifies Z band alternatively spliced PDZ-motif protein (zasp), encoding the only known Drosophila...
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