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Article

Zasp52 in Drosophila melanogaster indirect flight muscles can serve as a model system to investigate the function of clinical variants causing myopathies.

G3 (Bethesda, Md.) - 5 Aug 2026

Medina-Quintana José, Akbari-Gakieh Bijan, Lalonde Marie-Pier, Liu Taocheng, Schöck Frieder

Abstract excerpt

The sarcomere is the basic contractile unit of muscle fibers, bordered by Z-discs. In Drosophila, Z-disc structure and maintenance rely on actinin, and the Z-band alternatively spliced PDZ-motif protein 52 (Zasp52), a member of the Alp/Enigma family. Zasp52 has been shown to bind actin, actinin, and itself, but its full range of functions remains unclear, as a null mutant has not been previously analyzed. To...

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Identifiers

PMID: 42262929
DOI: 10.1093/g3journal/jkag148
PMCID: PMC13439939

Genes

LDB3

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 16 Oct 2026.

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