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Article

Reduction of acetate accumulation in Escherichia coli cultures for increased recombinant protein production.

Metabolic engineering - 1 Mar 2008

Wong Matthew S, Wu Steven, Causey Thomas B, Bennett George N, San Ka-Yiu

Abstract excerpt

The culture of Escherichia coli for the commercial production of recombinant proteins has increased significantly in recent years. The production of acetate as a byproduct retards cell growth, inhibits protein formation, and diverts carbon from biomass to protein product. Our approach to reducing acetate accumulation was to disable the phosphoenolpyruvate:sugar phosphotransferase system (PEP-PTS) by deleting the...

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Identifiers

PMID: 18164227
DOI: 10.1016/j.ymben.2007.10.003

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PTS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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