Article
Expression of galP and glk in a Escherichia coli PTS mutant restores glucose transport and increases glycolytic flux to fermentation products.
Biotechnology and bioengineering - 20 Sept 2003
Hernández-Montalvo Verónica, Martínez Alfredo, Hernández-Chavez Georgina, Bolivar Francisco, Valle Fernando, Gosset Guillermo
Abstract excerpt
In Escherichia coli, the uptake and phosphorylation of glucose is carried out mainly by the phosphotransferase system (PTS). Despite the efficiency of glucose transport by PTS, the required consumption of 1 mol of phosphoenolpyruvate (PEP) for each mol of internalized glucose represents a drawback for some biotechnological applications where PEP is a precursor of the desired product. For this reason, there is...
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