Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reactions of glyceraldehyde 3-phosphate dehydrogenase sulfhydryl groups with bis-electrophiles produce DNA-protein cross-links but not mutations.

Chemical research in toxicology - 1 Feb 2008

Loecken Elisabeth M, Guengerich F Peter

Abstract excerpt

The environmental contaminant 1,2-dibromoethane and diepoxybutane, an oxidation product of the important industrial chemical butadiene, are bis-functional electrophiles and are known to be mutagenic and carcinogenic. One mechanism by which bis-electrophiles can exert their toxic effects is through the induction of genotoxic and mutagenic DNA-peptide cross-links. This mechanism has been shown in systems...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Survival
Share to Cross-Linking Reagents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Environmental Pollutants

Share to Epoxy Compounds

Share to Glyceraldehyde-3-Phosphate Dehydrogenases

Share to Mutagens

Share to O(6)-Methylguanine-DNA Methyltransferase

Share to Sulfhydryl Compounds

Source

Open in PubMed Open full text

Identifiers

PMID: 18163542
DOI: 10.1021/tx7003618
PMCID: PMC4049368

Genes

GAPDH
AGT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reactions of glyceraldehyde 3-phosphate dehydrogenase sulfhydryl groups with bis-electrophiles produce DNA-protein cross-links but not mutations.PMID 18163542Read ↗

GSH-mediated S-transarylation of a quinone glyceraldehyde-3-phosphate dehydrogenase conjugate.Semantic proximity Read ↗

Alkyltransferase-mediated toxicity of 1,3-butadiene diepoxide.Semantic proximity Read ↗

DNA-protein crosslinks processed by nucleotide excision repair and homologous recombination with base and strand preference in E. coli model system.Semantic proximity Read ↗

Activation of bis-electrophiles to mutagenic conjugates by human O6-alkylguanine-DNA alkyltransferase.Semantic proximity Read ↗

Principles of covalent binding of reactive metabolites and examples of activation of bis-electrophiles by conjugation.Semantic proximity Read ↗

Detection and characterization of 1,2-dibromoethane-derived DNA crosslinks formed with O(6) -alkylguanine-DNA alkyltransferase.Semantic proximity Read ↗

1,N 2-Ethenoguanine, a Mutagenic DNA Adduct, Is a Primary Substrate of Escherichia coliMismatch-specific Uracil-DNA Glycosylase and Human Alkylpurine-DNA-N-GlycosylaseSemantic proximity Read ↗

Mutation in G6PD gene leads to loss of cellular control of protein glutathionylation: mechanism and implication.Semantic proximity Read ↗

Effect of O6-alkylguanine-DNA alkyltransferase on genotoxicity of epihalohydrins.Semantic proximity Read ↗

Interaction of human and bacterial AlkB proteins with DNA as probed through chemical cross-linking studies.Semantic proximity Read ↗

Oxidation-induced generation of a mild electrophile for proximity-enhanced protein-protein crosslinking.Semantic proximity Read ↗

Formation of 1,2:3,4-diepoxybutane-specific hemoglobin adducts in 1,3-butadiene exposed workers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.