Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alkyltransferase-mediated toxicity of 1,3-butadiene diepoxide.

Chemical research in toxicology - 1 Sept 2008

Kalapila Aley G, Loktionova Natalia A, Pegg Anthony E

Abstract excerpt

Human O(6)-alkylguanine-DNA alkyltransferase (hAGT) expression increases mutations and cytotoxicity following exposure to 1,3-butadiene diepoxide (BDO), and hAGT-DNA cross-links are formed in the presence of BDO. We have used hAGT mutants to investigate the mechanism of cross-link formation and genotoxicity. Formation of a hAGT-DNA conjugate in vitro was observed with C145S and C145A mutant proteins but was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Butadienes
Share to DNA
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Bacterial

Share to Epoxy Compounds

Share to Escherichia coli

Share to O(6)-Methylguanine-DNA Methyltransferase

Share to Rifampin

Source

Open in PubMed Open full text

Identifiers

PMID: 18712882
DOI: 10.1021/tx800178t
PMCID: PMC2614079

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alkyltransferase-mediated toxicity of 1,3-butadiene diepoxide.PMID 18712882Read ↗

Activation of bis-electrophiles to mutagenic conjugates by human O6-alkylguanine-DNA alkyltransferase.Semantic proximity Read ↗

The role of human O(6)-alkylguanine-DNA alkyltransferase in promoting 1,2-dibromoethane-induced genotoxicity in Escherichia coli.Semantic proximity Read ↗

DNA-protein crosslinks processed by nucleotide excision repair and homologous recombination with base and strand preference in E. coli model system.Semantic proximity Read ↗

Reactions of glyceraldehyde 3-phosphate dehydrogenase sulfhydryl groups with bis-electrophiles produce DNA-protein cross-links but not mutations.Semantic proximity Read ↗

Mutations induced by 1,3-butadiene metabolites, butadiene diolepoxide, and 1,2,3,4-diepoxybutane at the Hprt locus in CHO-K1 cells.Semantic proximity Read ↗

Effect of O6-alkylguanine-DNA alkyltransferase on genotoxicity of epihalohydrins.Semantic proximity Read ↗

<i>O</i> <sup>6</sup> -Alkylguanine-DNA Alkyltransferase Maintains Genomic Integrity During Peroxynitrite-Mediated DNA Damage by Forming DNA-Protein CrosslinksSemantic proximity Read ↗

1,3-butadiene: cancer, mutations, and adducts. Part II: Roles of two metabolites of 1,3-butadiene in mediating its in vivo genotoxicity.Semantic proximity Read ↗

Suppression of chemically induced and spontaneously occurring oxidative mutagenesis by three alleles of human OGG1 gene encoding 8-hydroxyguanine DNA glycosylase.Semantic proximity Read ↗

Single-nucleotide polymorphic variants of human glutathione transferase T1-1 differ in stability and functional properties.Semantic proximity Read ↗

Analysis of hprt mutations occurring in human TK6 lymphoblastoid cells following exposure to 1,2,3,4-diepoxybutane.Semantic proximity Read ↗

Interaction of mammalian O(6)-alkylguanine-DNA alkyltransferases with O(6)-benzylguanine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.