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Article

GSH-mediated S-transarylation of a quinone glyceraldehyde-3-phosphate dehydrogenase conjugate.

Chemical research in toxicology - 21 Nov 2011

Miura Takashi, Kakehashi Hidenao, Shinkai Yasuhiro, Egara Yuko, Hirose Reiko, Cho Arthur K, Kumagai Yoshito

Abstract excerpt

Many cellular proteins with reactive thiols form covalent bonds with electrophiles, thereby modifying their structures and activities. Here, we describe the recovery of a glycolytic protein, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), from such an electrophilic attack by 1,2-napthoquinone (1,2-NQ). GAPDH readily formed a covalent bond with 1,2-NQ through Cys152 at a low concentration (0.2 μM) in a cell-free...

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Source

Identifiers

PMID: 21827172
DOI: 10.1021/tx200025y

Genes

GAPDH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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