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Article

Formation of 1,2:3,4-diepoxybutane-specific hemoglobin adducts in 1,3-butadiene exposed workers.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Jan 2012

Boysen Gunnar, Georgieva Nadia I, Bordeerat Narisa K, Sram Radim J, Vacek Pamela, Albertini Richard J, Swenberg James A

Abstract excerpt

1,3-Butadiene (BD) is an important industrial chemical that is classified as a human carcinogen. BD carcinogenicity has been attributed to its metabolism to several reactive epoxide metabolites and formation of the highly mutagenic 1,2:3,4-diepoxybutane (DEB) has been hypothesized to drive mutagenesis and carcinogenesis at exposures experienced in humans. We report herein the formation of DEB-specific...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22003190
DOI: 10.1093/toxsci/kfr272
PMCID: PMC3243749

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