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Article

Detection and characterization of 1,2-dibromoethane-derived DNA crosslinks formed with O(6) -alkylguanine-DNA alkyltransferase.

Angewandte Chemie (International ed. in English) - 2 Dec 2013

Chowdhury Goutam, Cho Sung-Hee, Pegg Anthony E, Guengerich F Peter

Abstract excerpt

A combination of chemical modifications and LC-tandem MS was used for the structure elucidation of various ethylene crosslinks of DNA with O(6) -alkylguanine-DNA alkyltransferase (AGT, see picture). The elucidation of the chemical structures of such DNA-protein crosslinks is necessary to understand mechanisms of mutagenesis.

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Identifiers

PMID: 24130045
DOI: 10.1002/anie.201307580
PMCID: PMC4048925

Genes

AGT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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