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Article

Oxidation-induced generation of a mild electrophile for proximity-enhanced protein-protein crosslinking.

Chemical communications (Cambridge, England) - 19 Apr 2018

Shang X, Chen Y, Wang N, Niu W, Guo J

Abstract excerpt

We report a strategy to introduce a reactive electrophile into proteins through the conversion of a chemically inert group into a bioreactive group in response to an inducer molecule. This strategy was demonstrated by oxidation-induced and proximity-enhanced protein-protein crosslinking in the presence of a large excess of free nucleophile.

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Identifiers

PMID: 29629441
DOI: 10.1039/c8cc01639a
PMCID: PMC5908726

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