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Article

Effect of O6-alkylguanine-DNA alkyltransferase on genotoxicity of epihalohydrins.

Environmental and molecular mutagenesis - 1 Jul 2009

Kalapila Aley G, Loktionova Natalia A, Pegg Anthony E

Abstract excerpt

The effect of O(6)-alkylguanine-DNA alkyltransferase (AGT) on the toxicity and mutagenicity of epihalohydrins was studied. AGT is a DNA repair protein that protects cells from agents that produce genotoxic O(6)-alkylguanine lesions by transferring the alkyl group to an internal cysteine residue (Cys(145) in human AGT) in a single-step. This cysteine acceptor site is highly reactive and epihalohydrins reacted...

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Source

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Identifiers

PMID: 19472322
DOI: 10.1002/em.20491
PMCID: PMC2855547

Genes

AGT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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