Article
Genetic association tests in the presence of epistasis or gene-environment interaction.
Genetic epidemiology - 1 Nov 2008
Wang Kai
Abstract excerpt
A genetic variant is very likely to manifest its effect on disease through its main effect as well as through its interaction with other genetic variants or environmental factors. Power to detect genetic variants can be greatly improved by modeling their main effects and their interaction effects through a common set of parameters or "generalized association parameters" (Chatterjee et al. [2006] Am. J. Hum....
Topics
- Algorithms
- Alleles
- Computer Simulation
- Environmental Exposure
- Epistasis, Genetic
- Gene Frequency
- Genetic Variation
- Humans
- Likelihood Functions
- Models, Genetic
- Models, Statistical
- Normal Distribution
- Polymorphism, Single Nucleotide
- Regression Analysis
- Research Design