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Article

Activity-dependent phosphorylation of Ser187 is required for SNAP-25-negative modulation of neuronal voltage-gated calcium channels.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jan 2008

Pozzi Davide, Condliffe Steven, Bozzi Yuri, Chikhladze Maia, Grumelli Carlotta, Proux-Gillardeaux Véronique, Takahashi Masami, Franceschetti Silvana, Verderio Claudia, Matteoli Michela

Abstract excerpt

Synaptosomal-associated protein of 25 kDa (SNAP-25) is a SNARE protein that regulates neurotransmission by the formation of a complex with syntaxin 1 and synaptobrevin/VAMP2. SNAP-25 also reduces neuronal calcium responses to stimuli, but neither the functional relevance nor the molecular mechanisms of this modulation have been clarified. In this study, we demonstrate that hippocampal slices from Snap25(+/-) mice...

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Identifiers

PMID: 18162553
DOI: 10.1073/pnas.0706211105
PMCID: PMC2224210

Genes

VAMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Activity-dependent phosphorylation of Ser187 is required for SNAP-25-negative modulation of neuronal voltage-gated calcium channels.PMID 18162553Read ↗

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