Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SNAP-25 phosphorylation at Ser187 regulates synaptic facilitation and short-term plasticity in an age-dependent manner.

Scientific reports - 11 Aug 2017

Katayama Norikazu, Yamamori Saori, Fukaya Masahiro, Kobayashi Shizuka, Watanabe Masahiko, Takahashi Masami, Manabe Toshiya

Abstract excerpt

Neurotransmitter release is mediated by the SNARE complex, but the role of its phosphorylation has scarcely been elucidated. Although PKC activators are known to facilitate synaptic transmission, there has been a heated debate on whether PKC mediates facilitation of neurotransmitter release through phosphorylation. One of the SNARE proteins, SNAP-25, is phosphorylated at the residue serine-187 by PKC, but its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mice
Share to Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred ICR

Share to Neuronal Plasticity

Share to Phosphorylation

Share to Protein Processing, Post-Translational

Share to Serine

Share to Synaptosomal-Associated Protein 25

Source

Open in PubMed Open full text

Identifiers

PMID: 28801590
DOI: 10.1038/s41598-017-08237-x
PMCID: PMC5554206

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SNAP-25 phosphorylation at Ser187 regulates synaptic facilitation and short-term plasticity in an age-dependent manner.PMID 28801590Read ↗

SNAP-25 phosphorylation at Ser187 is not involved in Ca2+ or phorbolester-dependent potentiation of synaptic release.Semantic proximity Read ↗

Activity-dependent phosphorylation of Ser187 is required for SNAP-25-negative modulation of neuronal voltage-gated calcium channels.Semantic proximity Read ↗

Developmentally regulated switch in alternatively spliced SNAP-25 isoforms alters facilitation of synaptic transmission.Semantic proximity Read ↗

Inhibition of SNAP-25 phosphorylation at Ser187 is involved in chronic morphine-induced down-regulation of SNARE complex formation.Semantic proximity Read ↗

Effects of PKA-mediated phosphorylation of Snapin on synaptic transmission in cultured hippocampal neurons.Semantic proximity Read ↗

Molecular mechanisms determining conserved properties of short-term synaptic depression revealed in NSF and SNAP-25 conditional mutants.Semantic proximity Read ↗

A single amino acid mutation in SNAP-25 induces anxiety-related behavior in mouse.Semantic proximity Read ↗

Snapin facilitates the synchronization of synaptic vesicle fusion.Semantic proximity Read ↗

Essential functions of synapsins I and II in synaptic vesicle regulation.Semantic proximity Read ↗

Rasopathy-Associated Mutation Ptpn11D61Y has Age-Dependent Effect on Synaptic Vesicle Recycling.Semantic proximity Read ↗

Phosphorylation of synapsin domain A is required for post-tetanic potentiation.Semantic proximity Read ↗

Opposing functions of two sub-domains of the SNARE-complex in neurotransmission.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.