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Article

A single amino acid mutation in SNAP-25 induces anxiety-related behavior in mouse.

PloS one - 1 Jan 2011

Kataoka Masakazu, Yamamori Saori, Suzuki Eiji, Watanabe Shigeru, Sato Taku, Miyaoka Hitoshi, Azuma Sadahiro, Ikegami Shiro, Kuwahara Reiko, Suzuki-Migishima Rika, Nakahara Yohko, Nihonmatsu Itsuko, Inokuchi Kaoru, Katoh-Fukui Yuko, Yokoyama Minesuke, Takahashi Masami

Abstract excerpt

Synaptosomal-associated protein of 25 kDa (SNAP-25) is a presynaptic protein essential for neurotransmitter release. Previously, we demonstrate that protein kinase C (PKC) phosphorylates Ser(187) of SNAP-25, and enhances neurotransmitter release by recruiting secretory vesicles near to the plasma membrane. As PKC is abundant in the brain and SNAP-25 is essential for synaptic transmission, SNAP-25 phosphorylation...

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Source

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Identifiers

PMID: 21949876
DOI: 10.1371/journal.pone.0025158
PMCID: PMC3176821

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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