Article
Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 May 2005
Holmans Peter, Hamshere Marian, Hollingworth Paul, Rice Frances, Tunstall Nigel, Jones Sue, Moore Pamela, Wavrant DeVrieze Fabienne, Myers Amanda, Crook Richard, Compton Danielle, Marshall Helen, Meyer David, Shears Shantia, Booth Jeremy, Ramic Dzanan, Williams Nigel, Norton Nadine, Abraham Richard, Kehoe Pat, Williams Hywel, Rudrasingham Varuni, O'Donovan Mick, Jones Lesley, Hardy John, Goate Alison, Lovestone Simon, Owen Michael, Williams Julie
Abstract excerpt
We performed an affected sib-pair (ASP) linkage analysis to test for the effects of age at onset (AAO), rate of decline (ROD), and Apolipoprotein E (APOE) genotype on linkage to late-onset Alzheimer's disease (AD) in a sample comprising 428 sib-pairs. We observed linkage of mean AAO to chromosome 21 in the whole sample (max LOD = 2.57). This came entirely from the NIMH sample (max LOD = 3.62), and was strongest...
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