Article
A full genome scan for late onset Alzheimer's disease.
Human molecular genetics - 1 Feb 1999
Kehoe P, Wavrant-De Vrieze F, Crook R, Wu W S, Holmans P, Fenton I, Spurlock G, Norton N, Williams H, Williams N, Lovestone S, Perez-Tur J, Hutton M, Chartier-Harlin M C, Shears S, Roehl K, Booth J, Van Voorst W, Ramic D, Williams J, Goate A, Hardy J, Owen M J
Abstract excerpt
We have genotyped 292 affected sibling pairs (ASPs) with Alzheimer's disease (AD) according to NINCDS-ADRDA diagnostic criteria and with onset ages of >/=65 years using 237 microsatellite markers separated by an average distance of 16.3 cM. Data were analysed by SPLINK and MAPMAKER/SIBS on the wh...
Topics
- Age of Onset
- Alleles
- Alzheimer Disease
- Apolipoproteins E
- Chromosome Mapping
- DNA
- Family Health
- Female
- Genetic Predisposition to Disease
- Genome, Human
- Humans
- Lod Score
- Male