Article
Serum anti-p53 antibodies as a useful marker for prognosis of gastric carcinoma.
The International journal of biological markers - 1 Jan 2000
Mattioni M, Soddu S, Porrello A, D'Alessandro R, Spila A, Guadagni F
Abstract excerpt
Mutations in the TP53 gene are the most common genetic alterations in cancer. Accumulation of mutated protein may induce circulating anti-p53 antibodies (anti-p53Ab) in sera of cancer patients. The aim of our work was to evaluate the presence and prognostic value of anti-p53Ab in gastric cancer patients and to investigate whether their presence is related to p53 overexpression in tumor tissue. Anti-p53Ab were...
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