Article
Clinical significance of serum and ascitic p53 autoantibodies in epithelial ovarian carcinoma.
Cancer - 15 Mar 2000
Abendstein B, Marth C, Müller-Holzner E, Widschwendter M, Daxenbichler G, Zeimet A G
Abstract excerpt
BACKGROUND: Accumulation of mutated p53 in malignant cells can lead to the generation of anti-p53 autoantibodies in the serum and other body fluids of cancer patients. This retrospective study was performed to evaluate the prognostic significance of preoperative serum and ascitic anti-p53 antibodies in advanced ovarian carcinoma. METHODS: In 113 ovarian carcinoma patients who presented with significant amounts of...
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