Article
Utilizing the Jaccard index to reveal population stratification in sequencing data: a simulation study and an application to the 1000 Genomes Project.
Bioinformatics (Oxford, England) - 1 May 2016
Prokopenko Dmitry, Hecker Julian, Silverman Edwin K, Pagano Marcello, Nöthen Markus M, Dina Christian, Lange Christoph, Fier Heide Loehlein
Abstract excerpt
MOTIVATION: Population stratification is one of the major sources of confounding in genetic association studies, potentially causing false-positive and false-negative results. Here, we present a novel approach for the identification of population substructure in high-density genotyping data/next generation sequencing data. The approach exploits the co-appearances of rare genetic variants in individuals. The...
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