Article
Glial cell missing 1 regulates placental growth factor (PGF) gene transcription in human trophoblast.
Biology of reproduction - 1 May 2008
Chang Miao, Mukherjea Debashree, Gobble Ryan M, Groesch Kathleen A, Torry Ronald J, Torry Donald S
Abstract excerpt
Placental growth factor (PGF, previously known as PlGF) is prominently expressed by trophoblasts in human placenta, whereas most nontrophoblast cells express low levels of PGF mRNA under normal physiological conditions. We have shown that hypoxia decreases PGF expression in the trophoblast, but little is known about transcriptional regulation of PGF gene expression. We sought to determine promoter regions of the...
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