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Article

Hypoxia and Trophoblast Differentiation: A Key Role for PPARγ

14 Jun 2013

Abstract excerpt

Tissue oxygen tension regulates differentiation of multiple types of stem cells. In the placenta, hypoxia has been associated with abnormal trophoblast differentiation and placental insufficiency syndromes of preeclampsia (PE) and intrauterine growth restriction (IUGR). Peroxisome proliferator-activated receptor-γ (PPARγ) is a ligand-activated transcription factor involved in many cellular processes, including...

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PMID: 23767827
DOI: 10.1089/scd.2012.0596

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