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Hypoxia and loss of GCM1 expression prevent differentiation and contact inhibition in human trophoblast stem cells

24 Apr 2025

Abstract excerpt

), so we sought to determine the regulatory role of oxygen in human trophoblast stem cells (hTSCs). We find that low oxygen promotes hTSC self-renewal but inhibits differentiation to syncytiotrophoblast (STB) and extravillous trophoblast (EVT). The transcription factor GCM1 (glial cell missing transcription factor 1) is downregulated in low oxygen, and concordantly, there is substantial reduction of...

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PMID: 40280139
DOI: 10.1016/j.stemcr.2025.102481

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