Article

Hypoxia and loss of <i>GCM1</i> expression prevents differentiation and contact inhibition in human trophoblast stem cells

2024-09-10

Abstract excerpt

The placenta develops alongside the embryo and nurtures fetal development to term. During the first stages of embryonic development, due to low blood circulation, the blood and ambient oxygen supply is very low (∼1-2% O 2 ) and gradually increases upon placental invasion. While a hypoxic environment is associated with stem cell self-renewal and proliferation, persistent hypoxia may have severe effects on differen...

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Literature Corpus work: d5286cf2-6ac4-56d9-91cc-daf121586a8e
DOI: 10.1101/2024.09.10.612343

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