Up-Regulation ofc-metProtooncogene Product Expression through Hypoxia-Inducible Factor-1α Is Involved in Trophoblast Invasion under Low-Oxygen Tension

Abstract excerpt

During early pregnancy, the invasion of trophoblast cells into the decidua of the uterus is one of the essential steps in appropriate placentation. In this period, trophoblast cells are exposed to a relatively low-oxygen environment. The c-met protooncogene product (Met), which is a high-affinity receptor for hepatocyte growth factor, plays an important role in controlling the invasion of many types of cells. The...

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