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Article

Mechanism of Hypoxia-induced GCM1 Degradation

5 May 2009

Abstract excerpt

Preeclampsia is a major pregnancy-specific disorder affecting 5-7% of pregnancies worldwide. Although hypoxia caused by incomplete trophoblast invasion and impaired spiral arterial remodeling is thought to be a major cause of preeclampsia, how hypoxia affects placental development remains uncertain. GCM1 (glial cells missing homolog 1) is a transcription factor critical for placental development. In preeclampsia,...

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PMID: 19416964
DOI: 10.1074/jbc.m109.016170

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