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Article

Re-evaluation of the role of the protein S-C4b binding protein complex in activated protein C-catalyzed factor Va-inactivation.

Blood - 15 Mar 2008

Maurissen Lisbeth F A, Thomassen M Christella L G D, Nicolaes Gerry A F, Dahlbäck Björn, Tans Guido, Rosing Jan, Hackeng Tilman M

Abstract excerpt

Protein S expresses cofactor activity for activated protein C (APC) by enhancing the APC-catalyzed proteolysis at R(306) in factor Va. It is generally accepted that only free protein S is active and that complex formation with C4b-binding protein (C4BP) inhibits the APC-cofactor activity of protein S. However, the present study shows that protein S-C4BP expresses APC-cofactor activity and stimulates APC-catalyzed...

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Source

Identifiers

PMID: 18160668
DOI: 10.1182/blood-2007-06-089987

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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