Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The functional significance of the autolysis loop in protein C and activated protein C.

Thrombosis and haemostasis - 1 Jul 2005

Yang Likui, Manithody Chandrashekhara, Rezaie Alireza R

Abstract excerpt

The autolysis loop of activated protein C (APC) is five residues longer than the autolysis loop of other vitamin K-dependent coagulation proteases. To investigate the role of this loop in the zymogenic and anticoagulant properties of the molecule, a protein C mutant was constructed in which the autolysis loop of the protein was replaced with the corresponding loop of factor X. The protein C mutant was activated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha 1-Antitrypsin
Share to Anticoagulants
Share to Factor X

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Protein C

Share to Protein S

Share to Prothrombin

Share to Thrombin

Share to Vitamin K

Source

Open in PubMed Open full text

Identifiers

PMID: 16113785
DOI: 10.1160/TH05-02-0097
PMCID: PMC1193704

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The functional significance of the autolysis loop in protein C and activated protein C.PMID 16113785Read ↗

Function of the activated protein C (APC) autolysis loop in activated FVIII inactivation.Semantic proximity Read ↗

The role of autolysis loop in determining the specificity of coagulation proteases.Semantic proximity Read ↗

The structure-function relationship of activated protein C. Lessons from natural and engineered mutations.Semantic proximity Read ↗

Role of the activation peptide in the mechanism of protein C activation.Semantic proximity Read ↗

Engineering a disulfide bond to stabilize the calcium-binding loop of activated protein C eliminates its anticoagulant but not its protective signaling properties.Semantic proximity Read ↗

Characterization of a thrombomodulin binding site on protein C and its comparison to an activated protein C binding site for factor Va.Semantic proximity Read ↗

The anticoagulant function of coagulation factor V.Semantic proximity Read ↗

Basic residues in the 37-loop of activated protein C modulate inhibition by protein C inhibitor but not by alpha(1)-antitrypsin.Semantic proximity Read ↗

Structural basis for type I and type II deficiencies of antithrombotic plasma protein C: patterns revealed by three-dimensional molecular modelling of mutations of the protease domain.Semantic proximity Read ↗

Calcium inhibition of the activation of protein C by thrombin. Role of the P3 and P3' residues.Semantic proximity Read ↗

Characterisation of the molecular basis of protein S anticoagulant functionSemantic proximity Read ↗

The gamma-carboxyglutamic acid domain of anticoagulant protein S is involved in activated protein C cofactor activity, independently of phospholipid binding.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.