Article
Neurodegenerative mutation in cytoplasmic dynein alters its organization and dynein-dynactin and dynein-kinesin interactions.
The Journal of biological chemistry - 17 Dec 2010
Deng Wenhan, Garrett Caroline, Dombert Benjamin, Soura Violetta, Banks Gareth, Fisher Elizabeth M C, van der Brug Marcel P, Hafezparast Majid
Abstract excerpt
A single amino acid change, F580Y (Legs at odd angles (Loa), Dync1h1(Loa)), in the highly conserved and overlapping homodimerization, intermediate chain, and light intermediate chain binding domain of the cytoplasmic dynein heavy chain can cause severe motor and sensory neuron loss in mice. The mechanism by which the Loa mutation impairs the neuron-specific functions of dynein is not understood. To elucidate the...
Topics
- Animals
- Cytoplasmic Dyneins
- Dynactin Complex
- Kinesins
- Mice
- Mice, Mutant Strains
- Microtubule-Associated Proteins
- Mutation
- Neurodegenerative Diseases