Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Muscle spindle alterations precede onset of sensorimotor deficits in Charcot-Marie-Tooth type 2E.

Genes, brain, and behavior - 1 Feb 2017

Villalón E, Jones M R, Sibigtroth C, Zino S J, Dale J M, Landayan D S, Shen H, Cornelison D D W, Garcia M L

Abstract excerpt

Charcot-Marie-Tooth (CMT) is the most common inherited peripheral neuropathy, affecting approximately 2.8 million people. The CMT leads to distal neuropathy that is characterized by reduced motor nerve conduction velocity, ataxia, muscle atrophy and sensory loss. We generated a mouse model of CMT type 2E (CMT2E) expressing human neurofilament light E396K (hNF-LE396K ), which develops decreased motor nerve...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axons
Share to Charcot-Marie-Tooth Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Mice, Transgenic

Share to Muscular Atrophy

Share to Neural Conduction

Share to Neurofilament Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 27643807
DOI: 10.1111/gbb.12341
PMCID: PMC5290245

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Muscle spindle alterations precede onset of sensorimotor deficits in Charcot-Marie-Tooth type 2E.PMID 27643807Read ↗

Muscle pathology without severe nerve pathology in a new mouse model of Charcot-Marie-Tooth disease type 2E.Semantic proximity Read ↗

The <i>Nefl</i> <sup>E397K</sup> mouse model demonstrates muscle pathology and motor function deficits consistent with CMT2ESemantic proximity Read ↗

Novel neurofilament light (Nefl) E397K mouse models of Charcot-Marie-tooth type 2E (CMT2E) present early and chronic axonal neuropathy.Semantic proximity Read ↗

Novel neurofilament light ( <i>Nefl</i> ) E397K mouse models of Charcot-Marie-Tooth type 2E (CMT2E) present early and chronic axonal neuropathySemantic proximity Read ↗

Update on Charcot-Marie-Tooth disease.Semantic proximity Read ↗

Myelinated axons fail to develop properly in a genetically authentic mouse model of Charcot-Marie-Tooth disease type 2E.Semantic proximity Read ↗

Exacerbation of Charcot-Marie-Tooth type 2E neuropathy following traumatic nerve injury.Semantic proximity Read ↗

Charcot-Marie-Tooth neuropathies: diagnosis and management.Semantic proximity Read ↗

Junctions in Jeopardy: the neuromuscular junction is a selective pathological target in Charcot-Marie-Tooth disease.Semantic proximity Read ↗

Overlapping molecular pathological themes link Charcot-Marie-Tooth neuropathies and hereditary spastic paraplegias.Semantic proximity Read ↗

C698R Lrsam1 knock-in mouse model for CMT2PSemantic proximity Read ↗

Motor and sensory neuropathy due to myelin infolding and paranodal damage in a transgenic mouse model of Charcot-Marie-Tooth disease type 1C.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.