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Article

Permeabilization of E. coli K12 inner and outer membranes by bothropstoxin-I, A LYS49 phospholipase A2 from Bothrops jararacussu.

Toxicon : official journal of the International Society on Toxinology - 15 Mar 2008

Aragão Elisangela Aparecida, Chioato Lucimara, Ward Richard J

Abstract excerpt

Although lacking catalytic activity, the Lys49-PLA(2)s damage artificial membranes by a Ca(2+)-independent mechanism, and demonstrate a potent bactericidal effect. The relationship between the membrane-damaging activity and bactericidal effect of bothropstoxin-I (BthTx-I), a Lys49-PLA(2) from the venom of Bothrops jararacussu, was evaluated for the wild-type protein and a series of site-directed mutants in the...

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Identifiers

PMID: 18160090
DOI: 10.1016/j.toxicon.2007.11.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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