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Article

Intrinsic repair protects cells from pore-forming toxins by microvesicle shedding.

Cell death and differentiation - 1 May 2017

Romero Matthew, Keyel Michelle, Shi Guilan, Bhattacharjee Pushpak, Roth Robyn, Heuser John E, Keyel Peter A

Abstract excerpt

Pore-forming toxins (PFTs) are used by both the immune system and by pathogens to disrupt cell membranes. Cells attempt to repair this disruption in various ways, but the exact mechanism(s) that cells use are not fully understood, nor agreed upon. Current models for membrane repair include (1) patch formation (e.g., fusion of internal vesicles with plasma membrane defects), (2) endocytosis of the pores, and (3)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28186501
DOI: 10.1038/cdd.2017.11
PMCID: PMC5423106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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